Updated Quotation Notice - Rua Bioscience Rights (“RUARB")

Following the announcement from RUA regarding the extension of closing date for the rights offer from Monday, 24 November 2025 to Monday, 8 December 2025, please see attached an updated Quotation Notice. UPDATED QUOTATION NOTICE: NZX MAIN BOARD RUA BIOSCIENCE LIMITED (“RUARB”) RIGHTS Issuer: Rua Bioscience Limited (“RUA”) Ticker Code: RUARB ISIN: NZRUAE0006S6 Details of Issue: A pro-rata renounceable rights issue of 1 new share for every 3 existing shares held on the Record Date. Ratio (New: Existing): 1 : 3 Exercise Price: NZ$0.025 per new share Reference Price: Calculated as head share price prior to quotation minus the Exercise Price Issue Price Payable: In full on application Registrar: Computershare Investor Services Limited (“RMLT”) Settlement Status: NZCDC Settlement System Key Dates Ex Rights Date: Friday, 7 November 2025 Rights Commence Trading: Friday, 7 November 2025 Record Date: 5pm, Monday, 10 November 2025 Letters of Entitlement sent to Shareholders: Tuesday, 11 November 2025 Offer Opens: Tuesday, 11 November 2025 Rights Quotation Ceases: Monday, 8 December 2025 Offer Closes: Friday, 12 December 2025 Allotment and commencement of trading of New Shares (retail offer): Thursday, 18 December 2025 Mark Peterson Chief Executive Officer NZX Limited 20 November 2025